In Vivo Potential Anti-Inflammatory Activity of Melissa officinalis L. Essential Oil

Table 1

Effect of essential oil of Melissa  officinalis L. on carrageenan-induced rat paw edema.

Treatment groups	Dose mg/kg p.o.	Mean volume of edema (left paw-right paw) induced by carrageenan (mL)
		1 h 30 min	3 h	6 h
Control		0.17±0.013	0.26±0.01	0.34±0.023
Indomethacin	10	0.04±0.004^∗	0.07±0.005^∗	0.16±0.008^∗
EOMO	200	0.05±0.009^∗	0.1±0.011^∗	0.13±0.01^∗
EOMO	400	0.04±0.01^∗	0.09±0.008^∗	0.1±0.013^∗

Values are expressed as mean ± S.E.M. (𝑛=6), p.o.: oral route, 𝑛: number of animals per group, EOMO: essential oil of Melissa  officinalis  L., ^∗𝑃<0.001 statistically significant relative to the control and reference drug (Indomethacin).