In Vivo Potential Anti-Inflammatory Activity of Melissa officinalis L. Essential Oil

Table 3

Effect of essential oil of Melissa  officinalis  L. on experimental trauma-induced rat paw edema.

Treatment groups	Dose mg/kg p.o.	Mean volume of edema (left paw-right paw) induced by experimental trauma (mL)
		1 h 30 min	3 h	6 h
Control		0.153±0.005	0.22±0.021	0.36±0.015
Indomethacin	10	0.04±0.009^∗	0.03±0.01^∗	0.03±0.01^∗
EOMO	200	0.085±0.005^∗	0.05±0.007^∗	0.03±0.005^∗
EOMO	400	0.068±0.004^∗	0.04±0.004^∗	0.02±0.005^∗

Values are expressed as mean ± S.E.M. (𝑛=6), EOMO: essential oil of Melissa  officinalis  L., ^∗𝑃<0.001 statistically significant compared to the control and reference drug (Indomethacin).