Preparation and Evaluation of Intravaginal Ring Containing Drospirenone

Figure 11

Morphology of vaginal tissues after application of VCR containing DRSP. Drospirenone IVR cut into rod about 1 cm length was administered into the vagina of the rats. The vaginal tissues of three different experimental groups (n = 10 each) were used after 7th day and 21st day: sham-operated animals with normal diet (control group); blank reservoir ring administrated group (blank group); drug-loaded reservoir-type ring administrated group (experimental group) was isolated, fixed in 10% neutral carbonated-buffered formaldehyde, embedded in paraffin, and cut into slices. After hematoxylin-eosin staining, the slices were observed under a light microscope (×400).