Preparation and Evaluation of Intravaginal Ring Containing Drospirenone

Table 6

The results of API excipients compatibility testing under high temperature.

High temperature (60°C)	API and excipients
	Drospirenone	Drospirenone + PVPk30	Drospirenone + silicone elastomer
0 d
S (%)	0.03	0.08	0.03
T (%)	0.09	0.16	0.14
5 d
S (%)	0.02	0.03	0.03
T (%)	0.08	0.08	0.15
10 d
S (%)	0.08	0.08	0.03
T (%)	0.28	0.29	0.13

S: single impurities; T: total impurities; API: drospirenone.