Preparation and Evaluation of Intravaginal Ring Containing Drospirenone

Table 7

The results of API excipients compatibility testing under high humidity.

RH 92.5%	API and excipients
	Drospirenone	Drospirenone + PVPK30	Drospirenone + silicone elastomer
0 d
S (%)	0.03	0.08	0.03
T (%)	0.09	0.16	0.14
5 d
S (%)	0.02	0.03	0.03
T (%)	0.09	0.06	0.13
10 d
S (%)	0.07	0.08	0.03
T (%)	0.14	0.30	0.15

S: single impurities; T: total impurities; API: drospirenone.