Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis

<table>Schematic representation of methotrexate’s pharmacodynamic. Methotrexate (MTX) indirectly blocks the formation of dTMP by inhibiting DHF reductase. FH<sub>2</sub>, which accumulates following the inhibition of DHF reductase, in turn inhibits thymidylate synthase. DHF = dihydrofolate; FH<sub>2</sub> = dihydrofolic acid; FH<sub>4</sub> = tetrahydrofolic acid; dTMP = thymidine monophosphate; and dUMP = deoxyuridine monophosphate.</table>

Advances in Pharmacological and Pharmaceutical Sciences

fig1

Figure 1

Figure 1: Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis 