Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis

Table 3

DDIs between MTX and NSAIDs.

Drug	Mechanism	Effects	References
NSAIDs (indomethacin, ketoprofen, naproxen, and diclofenac)	Competition for tubular secretion via the HOAT-3	NSAIDs decrease the excretion of MTX with an increase in ADRs.	[47, 48]
COX-2 inhibitors Etoricoxib	Inhibition of HOAT-3	Decreased excretion of MTX with an increase in ADRs	[49]
Other COX-2 inhibitors (i.e., celecoxib and lumiracoxib)		No data	[50, 51]