Curcumin Ameliorates Methotrexate-Induced Nephrotoxicity in Rats
Figure 5
Effect of curcumin on localization of cyclooxygenase-2 (COX-2) immunoreactivity in rat renal cortex of methotrexate-induced nephrotoxicity in rats (×1000). ((a) and (b)) Sections from control and curcumin-treated groups show localized COX-2 expression in the macula densa cells (arrow). (c) Methotrexate-treated group shows high COX-2 expression in different degenerated cortical tubules. Note that some nuclei show positive COX-2 staining (arrow). (d) Methotrexate plus curcumin treated group shows little COX-2 staining in different cortical tubules. Note that COX-2 staining in the macula densa cells (arrow). PCT: proximal convoluted tubule; DCT: distal convoluted tubule.
