Curcumin Ameliorates Methotrexate-Induced Nephrotoxicity in Rats
Figure 6
Effect of curcumin on localization of cyclooxygenase-2 (COX-2) immunoreactivity in rat renal medulla of methotrexate-induced nephrotoxicity in rats (×1000). ((a) and (b)) Sections from control and curcumin-treated groups show absence of COX-2 expression in the medullary tubules. (c) Methotrexate-treated group shows most of the medullary tubules exhibiting COX-2 staining. (d) Methotrexate plus curcumin treated group shows some medullary tubules displaying COX-2 expression (arrow) while others show absence of COX-2 expression (arrowhead).
