Comparative In Vitro Effects of Calcineurin Inhibitors on Functional Vascular Relaxations of Both Rat Thoracic and Abdominal Aorta

Figure 1

The panel compares the concentration-inhibition response curves (CRC) to acetylcholine (ACh) determined in phenylephrine (PE—1 μM)-constricted thoracic ((a) and (b) panels) and abdominal ((c) and (d) panels) aortic rings with intact endothelium either in the presence or absence of cyclosporine (CsA—1 mg/mL) or tacrolimus (Tac—0.1 mg/mL) maintained in the incubation medium for a period of 30 min after isolation from 13-week-old male Sprague Dawley rats (𝑛=6). *𝑃<0.05 and **𝑃<0.01 compared to respective data in the control group.

(a) Thoracic Aorta

(b) Thoracic Aorta

(c) Abdominal Aorta

(d) Abdominal Aorta