Table 2: The comparative effects of in vitro incubation with either CsA (1 mg/mL) or Tac (0.1 mg/mL) for 30 min. Duration on sodium nitroprusside (SNP-) evoked vasodilator responses in phenylephrine (PE-1 µM)-constricted rat aortic rings with intact endothelium.

RegionIncubation conditionSNP-DRC: Mean ± SEM values
IC50

Thoracic aortaControl75 ± 4.0 nM 104% ± 4.4%
CsA (1.0 mg/mL)50 ± 19.0 nM96% ± 3.0%
Tac (0.1 mg/mL)58 ± 7.0 nM96% ± 1.5%

Abdominal aortaControl158 ± 24.2 nM110% ± 2.9%
CsA (1.0 mg/mL)342 ± 179.1 nM104% ± 5.3%
Tac (0.1 mg/mL)194 ± 52.4 nM105% ± 1.79%

Each value shown above is mean ± SEM of several experiments performed using aortic rings isolated from a minimum of 6 rats for each condition of incubation.