Comparative In Vitro Effects of Calcineurin Inhibitors on Functional Vascular Relaxations of Both Rat Thoracic and Abdominal Aorta

Table 2

The comparative effects of in vitro incubation with either CsA (1 mg/mL) or Tac (0.1 mg/mL) for 30 min. Duration on sodium nitroprusside (SNP-) evoked vasodilator responses in phenylephrine (PE-1 µM)-constricted rat aortic rings with intact endothelium.

Region	Incubation condition	SNP-DRC: Mean ± SEM values
		IC50	𝐼max
Thoracic aorta	Control	75 ± 4.0 nM	104% ± 4.4%
	CsA (1.0 mg/mL)	50 ± 19.0 nM	96% ± 3.0%
	Tac (0.1 mg/mL)	58 ± 7.0 nM	96% ± 1.5%
Abdominal aorta	Control	158 ± 24.2 nM	110% ± 2.9%
	CsA (1.0 mg/mL)	342 ± 179.1 nM	104% ± 5.3%
	Tac (0.1 mg/mL)	194 ± 52.4 nM	105% ± 1.79%

Each value shown above is mean ± SEM of several experiments performed using aortic rings isolated from a minimum of 6 rats for each condition of incubation.