About this Journal Submit a Manuscript Table of Contents
Advances in Pharmacological Sciences
Volume 2013 (2013), Article ID 805756, 7 pages
http://dx.doi.org/10.1155/2013/805756
Research Article

Comparative Evaluation of Anti-Inflammatory Activity of Curcuminoids, Turmerones, and Aqueous Extract of Curcuma longa

R&D Centre, Natural Remedies, Plot No. 5B, Veerasandra Indl. Area, 19th K.M. Stone, Hosur Road, Electronic City, Bangalore, Karnataka 560 100, India

Received 10 August 2013; Revised 5 November 2013; Accepted 18 November 2013

Academic Editor: Antonio Ferrer-Montiel

Copyright © 2013 Ashish Subhash Bagad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Egger, “In search of a germ theory equivalent for chronic disease,” Preventing Chronic Disease, vol. 9, pp. 1–7, 2012.
  2. Y. Mizuno, R. F. Jacob, and R. Preston Mason, “Inflammation and the development of atherosclerosis—effects of lipid-lowering therapy,” Journal of Atherosclerosis and Thrombosis, vol. 18, no. 5, pp. 351–358, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. CIHR Canadian Institutes of Health Research, “Inflammation in chronic disease initiative,” 2012, http://www.cihr-irsc.gc.ca/e/44070.html.
  4. S. Su, T. Wang, J.-A. Duan et al., “Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha,” Journal of Ethnopharmacology, vol. 134, no. 2, pp. 251–258, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Laine, R. Smith, K. Min, C. Chen, and R. W. Dubois, “Systematic review: the lower gastrointestinal adverse effects of non-steroidal anti-inflammatory drugs,” Alimentary Pharmacology and Therapeutics, vol. 24, no. 5, pp. 751–767, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Rodrigo, R. De Francisco, J. M. Pérez-Pariente et al., “Nimesulide-induced severe hemolytic anemia and acute liver failure leading to liver transplantation,” Scandinavian Journal of Gastroenterology, vol. 37, no. 11, pp. 1341–1343, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Tag, A. K. Das, and H. Loyi, “Anti-inflammatory plants used by the Khamti tribe of Lohit district in eastern Arunachal Pradesh, India,” Natural Product Radiance, vol. 6, no. 4, pp. 334–340, 2007. View at Scopus
  8. R. McCaleb, E. Leigh, and K. Morien, “Turmeric, Curcuma longa, Zingiberaceae,” in The Encyclopedia of Popular Herbs, pp. 374–381, CA: Prima Publishing, 2000.
  9. G. K. Jayaprakasha, L. Jagan Mohan Rao, and K. K. Sakariah, “Chemistry and biological activities of C. longa,” Trends in Food Science and Technology, vol. 16, no. 12, pp. 533–548, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. P. T. Trinidad, S. S. Rosario, P. D. L. Marco, C. M. Aida, and P. B. Melissa, “Zingiber officinale and Curcuma longa as potential functional foods/ingredients,” Food and Public Health, vol. 2, no. 2, pp. 1–4, 2012.
  11. O. P. Sharma, “Antioxidant activity of curcumin and related compounds,” Biochemical Pharmacology, vol. 25, no. 15, pp. 1811–1812, 1976. View at Publisher · View at Google Scholar · View at Scopus
  12. P. S. Negi, G. K. Jayaprakasha, L. J. M. Rao, and K. K. Sakariah, “Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture,” Journal of Agricultural and Food Chemistry, vol. 47, no. 10, pp. 4297–4300, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. J. L. Funk, J. B. Frye, J. N. Oyarzo, H. Zhang, and B. N. Timmermann, “Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.),” Journal of Agricultural and Food Chemistry, vol. 58, no. 2, pp. 842–849, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. B. B. Aggarwal, A. Kumar, and A. C. Bharti, “Anticancer potential of curcumin: preclinical and clinical studies,” Anticancer Research, vol. 23, no. 1, pp. 363–398, 2003. View at Scopus
  15. The Ayurvedic Pharmacopoeia of India by Ministry of Health & Family Welfare, Govt. of India, vol.1, 2001.
  16. S. Wu and Y. S. Guan, Chinese Pharmacopoeia Commission, Chinese Pharmacopoeia, 2010.
  17. J. S. Jurenka, “Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research,” Alternative Medicine Review, vol. 14, no. 2, pp. 141–153, 2009. View at Scopus
  18. M. B. Patil, S. V. Taralkar, V. S. Sakpal, S. P. Shewale, and R. S. Sakpal, “Extraction, isolation and evaluation of anti-inflammatory activity of Curcuminoids from Curcuma longa,” International Journal of Chemical Sciences and Applications, vol. 2, no. 3, pp. 172–174, 2011.
  19. V. B. Liju, K. Jeena, and R. Kuttan, “An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa L.,” Indian Journal of Pharmacology, vol. 43, no. 5, pp. 526–531, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. G. G. L. Yue, B. C. L. Chan, P.-M. Hon et al., “Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa,” Food and Chemical Toxicology, vol. 48, no. 8-9, pp. 2011–2020, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. S. S. Deshpande, A. D. Ingle, and G. B. Maru, “Chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz[α]anthracene-induced rat mammary tumorigenesis,” Cancer Letters, vol. 123, no. 1, pp. 35–40, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. M. A. Azuine, J. J. Kayal, and S. V. Bhide, “Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as benzo[α]pyrene-induced genotoxicity and carcinogenicity,” Journal of Cancer Research and Clinical Oncology, vol. 118, no. 6, pp. 447–452, 1992. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Suresh Kumar, A. K. Shetty, and P. V. Salimath, “Modulatory effect of fenugreek seed mucilage and spent turmeric on intestinal and renal disaccharidases in streptozotocin induced diabetic rats,” Plant Foods for Human Nutrition, vol. 60, no. 2, pp. 87–91, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. A. H. Atta and A. Alkofahi, “Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts,” Journal of Ethnopharmacology, vol. 60, no. 2, pp. 117–124, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. P. F. D'Arcy, E. M. Howard, P. W. Mugg leton, and S. B. Townsend, “The anti-inflammatory action of griseofulvin in experimental animals,” Journal of Pharmacy and Pharmacology, vol. 12, no. 1, pp. 659–665, 1960.
  26. D. M. Eisenberg, R. B. Davis, S. L. Ettner et al., “Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national survey,” Journal of the American Medical Association, vol. 280, no. 18, pp. 1569–1575, 1998. View at Scopus
  27. “The use of complementary and alternative medicine in the united states,” National Center for Complementary and Alternative Medicine, 2012, http://nccam.nih.gov/news/camstats/2007/camsurvey_fs1.htm.
  28. “Program profile: international liaison brings global vision to OAM,” Complementary and Alternative Medicine at the NIH, vol. 3, pp. 3–10, 1996.
  29. S. Beg, S. Swain, H. Hasan, M. A. Barkat, and M. S. Hussain, “Systematic review of herbals as potential anti-inflammatory agents: recent advances, current clinical status and future perspectives,” Pharmacognosy Reviews, vol. 5, no. 10, pp. 120–137, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. EMEA European Medicines Agency, “Assessment report on Curcuma longa L. Rhizoma Doc,” Tech. Rep. EMEA/HMPC/456848/2009, 2009.
  31. V. B. Badgujar, P. S. Jain, R. R. Patil, N. G. Haswani, and S. G. Chaudhari, “Anti-inflammatory activity of Helicteres isora L. stem bark extracts in rats,” Asian Journal of Pharmaceutical and Clinical Research, vol. 2, pp. 63–65, 2009.
  32. I. Igbe, F. P. Ching, and A. Eromon, “Anti-inflammatory activity of aqueous fruit pulp extract of Hunteria umbellata K. schum in acute and chronic inflammation,” Acta Poloniae Pharmaceutica, vol. 67, no. 1, pp. 81–85, 2010. View at Scopus
  33. R. I. Udegbunam, U. I. Asuzu, R. O. C. Kene, S. O. Udegbunam, and C. Nwaehujor, “Anti-nociceptive, anti-inflammatory and anti-oxidant effects of the methanol leaf extract of sterculia tragacantha lindl,” Journal of Pharmacology and Toxicology, vol. 12, no. 6, pp. 516–524, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. V. Elango, O. Carolin, and P. S. Raghu, “Anti-inflammatory activity of the flower extracts of Solanum nigrum in Rats,” Hygeia Journal For Drugs and Medicines, vol. 4, no. 1, pp. 59–62, 2012.
  35. A. Eidi, M. Eidi, V. Mozaffanan et al., “Antinociceptive and anti-inflammatory effects of ethanolic extract of Salvia syriaca L. in mice,” International Journal of Pharmacology, vol. 7, no. 3, pp. 394–399, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. H. Hosseinzadeh and H. M. Younesi, “Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice,” BMC Pharmacology, vol. 2, article 7, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. J. C. Zanini Jr., Y. S. Medeiros, A. B. Cruz, R. R. A. Yunes, and J. B. Calixto, “Action of compounds from Mandevilla velutina on croton oil-induced ear oedema in mice. A comparative study with steroidal and nonsteroidal antiinflammatory drugs,” Phytotherapy Research, vol. 6, no. 1, pp. 1–5, 1992. View at Scopus
  38. J. D. Richardson and M. R. Vasko, “Cellular mechanisms of neurogenic inflammation,” Journal of Pharmacology and Experimental Therapeutics, vol. 302, no. 3, pp. 839–845, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. R. P. Carlson, L. O'Neill-Davis, J. Chang, and A. J. Lewis, “Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents,” Agents and Actions, vol. 17, no. 2, pp. 197–204, 1985. View at Scopus
  40. M. Gupta, U. Mazumder, S. K. Ramanathan, and S. K. Thangavel, “Studies on anti-inflammatory, analgesic and anti-pyretic properties of methanol extract of Caesalpinia bonducella leaves in experimental animal models,” Iranian Journal of Pharmacology and Therapeutics, vol. 2, no. 2, pp. 30–34, 2003.
  41. R. K. N. Cuman, C. A. Bersani-Amado, and Z. B. Fortes, “Influence of type 2 diabetes on the inflammatory response in rats,” Inflammation Research, vol. 50, no. 9, pp. 460–465, 2001. View at Scopus
  42. K. F. Swingle and F. E. Shideman, “Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain anti-inflammatory agents,” Journal of Pharmacology and Experimental Therapeutics, vol. 183, no. 1, pp. 226–234, 1972. View at Scopus
  43. S. S. Kumar, T. Sivakumar, M. J. Chandrasekar, and B. Suresh, “Evaluation of anti-inflammatory activity of Eclipta alba in rats,” Ancient Science of Life, vol. 24, no. 3, pp. 112–118, 2005.
  44. C. V. Chandrasekaran, K. Sundarajan, J. R. Edwin, G. M. Gururaja, D. Mundkinajeddu, and A. Agarwal, “Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction,” Pharmacognosy Research, vol. 5, no. 2, pp. 71–79, 2013.
  45. R. D. Granstein, M. R. Deak, S. L. Jacques et al., “The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wounding model,” Journal of Investigative Dermatology, vol. 93, no. 1, pp. 18–27, 1989. View at Scopus
  46. A. Mallat, A.-M. Preaux, S. Blazejewski, J. Rosenbaum, D. Dhumeaux, and P. Mavier, “Interferon alfa and gamma inhibit proliferation and collagen synthesis of human Ito cells in culture,” Hepatology, vol. 21, no. 4, pp. 1003–1010, 1995. View at Scopus
  47. R. Yegnanarayan, A. P. Saraf, and J. H. Balwani, “Comparison of anti inflammatory activity of various extracts of Curcuma longa (Linn),” Indian Journal of Medical Research, vol. 64, no. 4, pp. 601–608, 1976. View at Scopus
  48. Y. Abe, S. Hashimoto, and T. Horie, “Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages,” Pharmacological Research, vol. 39, no. 1, pp. 41–47, 1999. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Schaffer, P. M. Schaffer, J. Zidan, and G. B. Sela, “Curcuma as a functional food in the control of cancer and inflammation,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 14, no. 6, pp. 588–597, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. G. G. L. Yue, B. C. L. Chan, P.-M. Hon et al., “Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa,” International Journal of Biological Macromolecules, vol. 47, no. 3, pp. 342–347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. R. Gonda, K. Takeda, N. Shimizu, and M. Tomoda, “Characterization of a neutral polysaccharide having activity on the reticuloendothelial system from the rhizome of Curcuma longa,” Chemical and Pharmaceutical Bulletin, vol. 40, no. 1, pp. 185–188, 1992. View at Scopus
  52. K. I. Kim, K. S. Shin, W. J. Jun et al., “Effects of polysaccharides from rhizomes of Curcuma zedoaria on macrophage functions,” Bioscience, Biotechnology and Biochemistry, vol. 65, no. 11, pp. 2369–2377, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. A.-J. Kim, Y.-O. Kim, J.-S. Shim, and J.-K. Hwang, “Immunostimulating activity of crude polysaccharide extract isolated from Curcuma xanthorrhiza Roxb,” Bioscience, Biotechnology and Biochemistry, vol. 71, no. 6, pp. 1428–1438, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. H. Wang, X. Zhang, and C. Fusheng, “Antioxidant activity of bioactive polysaccharides isolated from natural sources,” Journal of Animal Science and Biotechnology, vol. 2, no. 4, pp. 230–238, 2011.
  55. K. Madhu, K. Chanda, and M. J. Saji, “Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial,” Inflammopharmacology, vol. 21, no. 2, pp. 129–362, 2013.