Table 2: Effect of curcuminoids, turmerones, and COFAE on cotton pellet-induced granuloma in rats.

Weight of cotton pellets (mg) (wet)Inhibition (%) Weight of cotton pellets (mg) (dry)Inhibition (%)

Vehicle control (10 mL/kg)228.6 ± 7.5051.9 ± 1.10
Dexamethasone (0.5 mg/kg)101.2 ± 5.7*55.722.7 ± 1.9*56.2
Diclofenac (5 mg/kg)111.0 ± 10.4*51.428 ± 1.7*46.0
Curcuminoids (5 mg/kg)143.2 ± 7.4*37.332 ± 2.0*38.3
Curcuminoids (25 mg/kg)127.5 ± 12.4*44.231.4 ± 0.6*39.4
Curcuminoids (125 mg/kg)132.9 ± 9.6*41.834.7 ± 1.2*33.1
Turmerones (0.05 mL/kg)140.1 ± 13.5*38.734.5 ± 1.9*33.5
Turmerones (0.1 mL/kg)129.0 ± 3.7*43.533.0 ± 1.0*36.2
Turmerones (0.15 mL/kg)142.7 ± 8.6*37.533.0 ± 0.7*36.2
COFAE (45 mg/kg)127.4 ± 4.7*44.231.7 ± 1.7*38.7
COFAE (90 mg/kg)131.0 ± 6.6*42.634.1 ± 0.9*34.1
COFAE (180 mg/kg)144.2 ± 4.8*36.935.2 ± 1.3*32.1

Values are expressed as mean ± SEM; ; P ≤ 0.05 treated groups versus vehicle control.