Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
Table 2
Effects of E. speciosa extracts and fractions on gastric acid secretion and ulceration in pylorus ligated rats.
Treatment
Dose (mg/kg)
Ulcer index
% Inhibition
Gastric mucus (mg)
Gastric juice (mL)
Gastric pH
Gastric acidity (mE/L)
Control
—
3.88 ± 0.21
—
45.04 ± 5.09
5.07 ± 0.20
2.66 ± 0.15
79.40 ± 5.63
CH3OH/CH2CL2
100
2.35 ± 0.05
39.43
78.20 ± 3.53***
2.04 ± 0.29**
3.95 ± 0.16***
46.00 ± 6.33**
CH3OH/CH2CL2
200
0.00 ± 0.00***
100
98.47 ± 3.67***
1.81 ± 0.13***
4.01 ± 0.17***
38.60 ± 3.90***
CH2CL2 fraction
100
3.20 ± 0.17
17.53
51.13 ± 2.95
2.14 ± 0.32***
3.54 ± 0.19**
55.60 ± 6.57*
CH2CL2 fraction
200
1.30 ± 0.37***
66.49
84.74 ± 6.06***
1.96 ± 0.10***
3.94 ± 0.09***
43.20 ± 3.65***
Eth. Acet. fraction
100
3.40 ± 0.19
12.37
60.70 ± 2.83**
5.30 ± 0.26
2.94 ± 0.06
71.60 ± 4.06
Eth. Acet. fraction
200
2.30 ± 0.38*
40.72
65.90 ± 2.33**
4.93 ± 0.36
3.40 ± 0.09
59.70 ± 3.58
Hexane fraction
100
2.77 ± 0.16*
28.60
70.72 ± 2.73***
4.54 ± 0.21
3.45 ± 0.24**
64.20 ± 6.91
Hexane fraction
200
2.40 ± 0.20
38.14
79.89 ± 3.89***
4.01 ± 0.32
3.52 ± 0.39**
54.90 ± 5.92
CH3OH fraction
100
3.43 ± 0.16
11.60
65.87 ± 2.70***
5.16 ± 0.21
3.06 ± 0.13
67.00 ± 6.12
CH3OH fraction
200
2.90 ± 0.19
25.25
67.33 ± 2.00***
5.01 ± 0.19
3.40 ± 0.25**
62.22 ± 5.76*
Aqueous extract
100
1.46 ± 0.06***
62.37
79.20 ± 3.24***
4.70 ± 0.30
3.01 ± 0.15**
63.40 ± 4.10*
Aqueous extract
200
1.00 ± 0.27***
74.23
92.19 ± 3.05***
2.10 ± 0.17***
3.97 ± 0.13***
40.02 ± 2.56***
Cimetidine
50
1.60 ± 0.43***
58.76
87.47 ± 3.76***
2.06 ± 0.28***
4.31 ± 0.15***
33.40 ± 4.32***
N = 5 rats per treatment; *P < 0.05, statistically significant relative to control; **P < 0.01, statistically highly significant relative to control; ***P < 0.001, statistically very highly significant relative to control.
