Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
Table 3
Effects of orally administered E. speciosa on histamine-induced gastric ulcers and gastric secretion in rats.
Treatment
Dose (mg/kg)
Ulcer index (mean + SEM)
% Inhibition
Mucus production (mg) (mean + SEM)
Volume of gastric juice (mL) (mean + SEM)
Gastric pH (mean + SEM)
Gastric acidity (mEq/L) (mean + SEM)
Control
—
4.12 ± 0.16
—
52.83 ± 2.96
6.87 ± 0.31
2.37 ± 0.04
86.50 ± 2.98
CH3OH/CH2Cl2
200
0.00 ± 0.00***
100.00
92.13 ± 2.89***
3.07 ± 0.18***
4.74 ± 0.34***
39.50 ± 3.19***
CH2Cl2 fraction
200
1.57 ± 0,65***
61.89
87.32 ± 6.91***
3.32 ± 0.38***
4.47 ± 0.27***
49.80 ± 4.14***
Aqueous extract
200
1.90 ± 0.29***
53.88
85.05 ± 4.21***
3.50 ± 0.45***
4.33 ± 0.23***
59.00 ± 4.08***
Cimetidine
100
0.0 ± 0.00***
100.00
88.8 ± 3.62***
2.28 ± 0.20***
4.96 ± 0.24***
34.60 ± 3.33***
N = 5 rats per treatment; *P < 0.05, statistically significant relative to control; **P < 0.01, statistically highly significant relative to control; ***P < 0.001, statistically very highly significant relative to control.
