Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
Table 5
Effects of duodenally administered aqueous extract of E. speciosa on gastric ulceration and secretion induced by histamine in rats.
Treatment
Dose (mg/kg)
Ulcer index (mean + SEM)
% Inhibition
Mucus production (mg) (mean + SEM)
Volume of gastric juice (mL) (mean + SEM)
Gastric pH (mean + SEM)
Gastric acidity (mEq/L) (mean + SEM)
Control
—
4.07 ± 0.22
—
59.06 ± 2.30
6.64 ± 0.24
2.29 ± 0.06
88.30 ± 3.56
E. speciosa
200
2.40 ± 0.19***
41.03
84.82 ± 2.69***
4.54 ± 0.21***
3.99 ± 0.16***
54.60 ± 2.70***
E. speciosa
400
0.00 ± 0.00***
100.00
101.69 ± 3.89***
2.54 ± 0.13***
4.65 ± 0.10***
28.50 ± 1.30***
Ranitidine
100
1.91 ± 0.33***
53.00
89.87 ± 2.01***
2.02 ± 0.15***
5.02 ± 0.17***
36.36 ± 1.46***
N = 5 rats per treatment; ***P < 0.001; statistically very highly significant relative to control.
