Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
Table 6
Effects of duodenally administered aqueous extract of E. speciosa on gastric ulceration and secretion induced by carbachol in rats.
Treatment
Dose (mg/kg)
Ulcer index (mean + SEM)
% Inhibition
Mucus production (mg) (mean + SEM)
Volume of gastric juice (mL) (mean + SEM)
Gastric pH (mean + SEM)
Gastric acidity (mEq/L) (mean + SEM)
Control
—
3.90 ± 0.19
—
56.36 ± 3.35
6.71 ± 0.19
2.72 ± 0.07
85.50 ± 2.31
E. speciosa
200
2.02 ± 0.20***
48.21
77.60 ± 2.78***
3.97 ± 0.25***
4.15 ± 0.12***
51.40 ± 3.97***
E. speciosa
400
0.00 ± 0.00***
100.00
103.20 ± 3.19***
2.37 ± 0.15***
5.26 ± 0.12***
28.80 ± 1.38***
Ranitidine
100
1.76 ± 0.23***
55.00
82.34 ± 3.48***
2.48 ± 0.19***
4.96 ± 0.28***
34.20 ± 1.42***
N = 5 rats per treatment; ***P < 0.001; statistically very highly significant relative to control.
