Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways
Table 8
Effects of orally administered aqueous extract of E. speciosa on gastric ulceration and secretion in pylorus-ligated rats treated with indomethacin/carbachol.
Treatment
Dose (mg/kg)
Ulcer index (mean + SEM)
% Inhibition
Mucus production (mg) (mean + SEM)
Volume of gastric juice (mL) (mean + SEM)
Gastric pH (mean + SEM)
Gastric acidity (mEq/L) (mean + SEM)
Control
—
4.13 ± 0.21
—
38.87 ± 4.59
7.32 ± 0.26
2.64 ± 0.15
92.10 ± 4.39
E. speciosa
200
3.10 ± 0.25**
24.94
60.63 ± 5.67*
5.14 ± 0.29***
3.96 ± 0.08***
59.50 ± 4.36***
E. speciosa
400
2.31 ± 0.13***
44.07
74.01 ± 6.90**
4.16 ± 0.31***
4.77 ± 0.07***
44.00 ± 4.08***
Ranitidine
100
2.03 ± 0.20***
50.85
49.02 ± 5.31
3.64 ± 0.30***
5.09 ± 0.25***
35.05 ± 3.03***
N = 5 rats per treatment; *P < 0.05, statistically significant relative to control; **P < 0.01, statistically highly significant relative to control; ***P < 0.001, statistically very highly significant relative to control.
