Advances in Pharmacological and Pharmaceutical Sciences

Research Article

Influence of Flunixin on the Disposition Kinetic of Cefepime in Goats

Table 1

Mean (±SE) kinetic parameters of cefepime (10 mg/kg b.w.) alone and in combination with flunixin (2.2 mg/kg b.w.) following a single intravenous injection in goats (n = 6).


Parameter	Units	Cefepime alone	Cefepime + flunixin

	h	0.20 ± 0.004	0.20 ± 0.003
Vc	L kg⁻¹	0.18 ± 0.007	0.18 ± 0.006
Vd_(area)	L kg⁻¹	0.46 ± 0.02	0.48 ± 0.03
Vd_ss	L kg⁻¹	0.44 ± 0.01	0.47 ± 0.04
	h⁻¹	2.17 ± 0.04	2.26 ± 0.09
	h⁻¹	1.47 ± 0.09	1.40 ± 0.04
	h⁻¹	0.49 ± 0.02	0.50 ± 0.03
	h	3.34 ± 0.12	3.50 ± 0.23
AUC_(0-inf)	μg mL⁻¹ h⁻¹	102.38 ± 8.61	103.91 ± 10.08
MRT	h	3.35 ± 0.22	3.48 ± 0.24
Cl_B	L kg⁻¹ h⁻¹	0.098 ± 0.0004	0.096 ± 0.0003

: distribution half-life; Vc: apparent volume of central compartment; Vd_(area): apparent volume of distribution calculated by area method; Vd_ss: volume of distribution at steady state; : first-order constant for transfer from central to peripheral compartment; : first-order constant for transfer from peripheral to central compartment; : elimination rate constant; : elimination half-life; AUC_(0-inf): area under serum concentration-time curve; MRT: mean residence time; Cl_B: total body clearance.