Influence of Flunixin on the Disposition Kinetic of Cefepime in Goats

Table 2

Mean (±SE) kinetic parameters of cefepime (10 mg/kg b.w.) alone and in combination with flunixin (2.2 mg/kg b.w.) following a single intramuscular injection in goats (n = 6).

Parameter	Units	Cefepime alone	Cefepime + flunixin
𝑇1/2(ab)	h	0.25 ± 0.02	0.28 ± 0.03
𝑇1/2(el)	h	3.44 ± 0.31	3.50 ± 0.22
𝐶max	μg·mL^−1	16.49 ± 0.53	19.03 ± 0.71*
𝑇max	h	0.91 ± 0.08	1.01 ± 0.07
AUC(0-inf)	μg·h·mL^−1	94.87 ± 3.89	98.99 ± 4.01
MRT	h	4.01 ± 0.33	4.08 ± 0.28

∗P < 0.05 significant difference.
𝑇_1/2(ab): absorption half-life; 𝑇_1/2(el): elimination half-life; 𝐶_max: maximum serum concentration; 𝑇_max: time to peak serum concentration; AUC_(0-inf): area under serum concentration-time curve; MRT: mean residence time.