Figure 3: (a) Effect of PECQ on mean thickness of cortical bone. Thickness of the cortical bone significantly decreased in diabetic control (DC) rats when compared to normal control (NC) rats. Treatment with two different doses of PECQ (DC + CQ1 and DC + CQ2) or with insulin (DC + INS) significantly increased the bone thickness in diabetic rats when compared to nontreated diabetic rats. when compared to NC group; , when compared to DC group. (b) Photomicrographs of cortical bone. Thickness of the cortical bone was significantly less in the diabetic control group (DC) when compared to normal control group (NC). Further treatment with two doses of the PECQ (DC + CQ1, DC + CQ2) and insulin (DC + INS) improved the cortical bone growth. C: cortical bone; M: medullary cavity; H and E staining, scale bar: 200 μm.