Antihyperglycemic Activity of Houttuynia cordata Thunb. in Streptozotocin-Induced Diabetic Rats

Table 3

Effect of HC on other biochemical parameters.

Group (𝑛=6)	Treatment (dose in mg/kg)	CRTN (mg/dL) 21 day	BUN (mg/dL) 21 day	TPR (g/dL) 21 day
I	NC	0.641±0.055	21.908±1.392	0.717±0.012
II	DC	1.165±0.135^a	57.906±4.831^a	0.615±0.011^a
III	Glib (10)	0.59±0.019^b	35.241±2.654^a,b	0.723±0.012^b
IV	HC (100)	1.039±0.087^a,c	52.573±2.474^a,c	0.614±1.028^a,c
V	HC (200)	0.792±0.095^b	44.862±2.143^a,b	0.646±1.017^a,c
VI	HC (400)	0.724±0.074^b	39.745±1.793^a,b,d	0.697±0.0.02^b,d

Values are mean ± SEM of 6 animals in each group. One-way ANOVA showed a significant difference in drug treatment between the groups for HC for total creatinine (CRTN), blood urea nitrogen (BUN), and total protein (TPR); ^a𝑃<0.05 compared to normal control; ^b𝑃<0.05 compared to diabetic control; ^c𝑃<0.05 compared to glibenclamide; ^d𝑃<0.05 compared to HC 100; ^e𝑃<0.05 compared to HC 200 (one-way ANOVA followed by Tukey’s multiple comparison test).