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Advances in Pharmacological Sciences
Volume 2014 (2014), Article ID 924706, 6 pages
http://dx.doi.org/10.1155/2014/924706
Research Article

Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats

1Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Qaliobiya 13736, Egypt
2Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt
3Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Minoufiya 32897, Egypt

Received 14 November 2013; Revised 13 December 2013; Accepted 13 December 2013; Published 3 February 2014

Academic Editor: Berend Olivier

Copyright © 2014 Mohamed Aboubakr et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was designed to investigate the possible developmental teratogenicity of norfloxacin in rats. Forty pregnant female rats were divided into four equal groups. Group A received norfloxacin in a dose of 500 mg/kg b wt/day orally from 6th to 15th day of gestation. Groups B and C received 1000 and 2000 mg/kg b wt/day orally for the same period, respectively; Group D behaved as control and received 0.5 mL distilled water orally for the same period. The dams were killed on 20th day of gestation and their fetuses were subjected to morphological, visceral, and skeletal examinations. Norfloxacin significantly decreased the number of viable fetuses, increased the number of resorbed fetuses, and induced retardation in growth of viable fetuses; some visceral and skeletal defects in these fetuses were seen and these effects were dose dependant. Conclusively, norfloxacin caused some fetal defects and abnormalities, so it is advisable to avoid using this drug during pregnancy.