Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats

Table 1

Effect of norfloxacin on fetuses obtained from pregnant female rats after repeated oral administration of 500, 1000, and 2000 mg norfloxacin/kg⋅b⋅wt from 6th to 15th day of pregnancy once daily (𝑛=10).

Parameters	Control group	500 mg/kg·b·wt; (A)	1000 mg/kg·b·wt; (B)	2000 mg/kg·b·wt; (C)
Number of female rats	10	10	10	10
Number of viable fetuses	91 (100%)	80 (98.88%)	61 (89.71%)	39 (68.42%)
Number of dead fetuses	0	0	2 (2.94%)	7 (12.28%)
Number of resorbed fetuses	0	1 (1.23%)	5 (7.35%)	11 (19.30%)
Total used	91	81	68	57
Fetal body weight (gm)	4.36±0.79	3.71±0.68	3.19±0.54	2.78±0.47
Fetal crown-rump length (cm)	4.29±0.64	3.74±0.71	3.28±0.61	3.01±0.59

%: percent in relation to the total number of examined fetuses.