Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats

Table 2

Visceral abnormalities in fetuses obtained from pregnant female rats after repeated oral administration of 500, 1000, and 2000 mg norfloxacin per kg⋅b⋅wt once daily from 6th to 15th day of pregnancy once daily (𝑛=15).

Parameters	Control group	500 mg/kg·b·wt; (A)	1000 mg/kg·b·wt; (B)	2000 mg/kg·b·wt; (C)
Number of examined fetuses	15	15	15	15
Brain diverticulum	—	8 (53.33%)	9 (60%)	12 (80%)
Thymus hypoplasia	—	6 (40%)	8 (53.33%)	9 (60%)
Lung hypoplasia	—	9 (60%)	9 (60%)	11 (73.33%)
Heart enlargement	—	8 (53.33%)	9 (60%)	12 (80%)
Liver enlargement	—	10 (66.67%)	12 (80%)	14 (93.33%)
Suprarenal gland enlargement	—	7 (46.67%)	8 (53.33%)	11 (73.33%)

%: percent of total abnormalities in relation to the number of examined fetuses.