Table 2: Visceral abnormalities in fetuses obtained from pregnant female rats after repeated oral administration of 500, 1000, and 2000 mg norfloxacin per kg b wt once daily from 6th to 15th day of pregnancy once daily ( ).

ParametersControl group500 mg/kg·b·wt
(A)
1000 mg/kg·b·wt
(B)
2000 mg/kg·b·wt
(C)

Number of examined fetuses15151515
Brain diverticulum8 (53.33%)9 (60%)12 (80%)
Thymus hypoplasia6 (40%)8 (53.33%)9 (60%)
Lung hypoplasia9 (60%)9 (60%)11 (73.33%)
Heart enlargement8 (53.33%)9 (60%)12 (80%)
Liver enlargement10 (66.67%)12 (80%)14 (93.33%)
Suprarenal gland enlargement7 (46.67%)8 (53.33%)11 (73.33%)

%: percent of total abnormalities in relation to the number of examined fetuses.