Table 3: Skeletal abnormalities in fetuses obtained from pregnant female rats after repeated oral administration of 500, 1000, and 2000 mg norfloxacin/kg b wt from 6th to 15th day of pregnancy once daily ( ).

ParametersControl group500 mg/kg·b·wt
(A)
1000 mg/kg·b·wt
(B)
2000 mg/kg·b·wt
(C)

Number of examined fetuses15151515
Impairment of skull ossification3 (20%)5 (33.33%)8 (53.33%)
Absence or dislocation of sternebrae2 (13.33%)3 (20%)5 (33.33%)
Reduction or absence of caudal vertebrae5 (33.33%)6 (40%)10 (66.67%)
Absence of digit's bone of fore limb3 (20%)4 (26.67%)9 (60%)
Absence of digit's bone of hind limb2 (12.33%)3 (20%)7 (46.67%)
Absence of some metatarsal bone3 (20%)4 (26.67%)6 (40%)
Absence of some metacarpal bone2 (12.33%)4 (26.67%)5 (33.33%)

%: percent of total abnormalities in relation to the number of examined fetuses.