Research Article

Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma

Table 3

Pharmacokinetic parameters of stephaglabrine in rabbit plasma samples after intramuscular injection.

Animal (ID)Dosage, mg , ng/mL , min , mināˆ’1 , mināˆ’1 , min , ng/mLAUC15, ng*min/mL

ST010.50 900.010.00513910.571661
ST020.50 900.0250.00611521.43187
ST030.45 900.02n/an/an/an/a
ST040.45 900.0130.0079922.52516
ST050.50 900.020.00611815.32217
ST060.50 900.0230.00712117.12769