Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice

Table 2

Effects of 5-fluorouracil (20 mg/kg), spirulina (200 or 800 mg/kg), and their combination on hematological parameters of EAC tumor-bearing mice.

	EAC	FU	SP200	SP800	FU/SP200
RBC (10^12/L)	7.6 ± 0.27	6.8 ± 0.27	6.9 ± 0.77	7.7 ± 0.48	7.1 ± 0.36
HGB (g/L)	11.4 ± 0.37	9.8 ± 0.41	10.1 ± 1.1	10.8 ± 0.65	10.3 ± 0.45
HCT (%)	46.8 ± 1.3	37.6 ± 1.5	36.1 ± 4.1	37.8 ± 2.3	33.8 ± 1.5
MCV (fL)	61.5 ± 0.9	55.3 ± 2.3	51.6 ± 0.6	49.4 ± 1.5	47.8 ± 1.5
PT (10^9/L)	737 ± 64	959 ± 102	947 ± 39	806 ± 80	1403 ± 160
PCT (%)	0.47 ± 0.05	0.69 ± 0.08	0.59 ± 0.04	0.54 ± 0.07	1.0 ± 0.12
WBC (10^9/L)	8.1 ± 0.81	6.2 ± 1.4	10.2 ± 2.1	10.7 ± 2.0	8.9 ± 3.3
LYM (10^9/L)	7.3 ± 0.75	4.9 ± 0.97	7.8 ± 1.6	7.3 ± 1.3	6.9 ± 2.3
GRA (10^9/L)	0.28 ± 0.08	0.41 ± 0.17	0.48 ± 0.19	0.55 ± 0.19	0.53 ± 0.27

Values are expressed as mean ± SEM (). EAC: Ehrlich ascites carcinoma tumor-bearing mice; FU: Ehrlich ascites carcinoma tumor-bearing mice treated with 5-fluorouracil (20 mg/kg); SP200: Ehrlich ascites carcinoma tumor-bearing mice treated with spirulina (200 mg/kg); SP800: Ehrlich ascites carcinoma tumor-bearing mice treated with spirulina (800 mg/kg); FU/SP200: Ehrlich ascites carcinoma tumor-bearing mice treated with 5-fluorouracil (20 mg/kg) plus spirulina (200 mg/kg). RBC: red blood cell count; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; PT: platelet count; PCT: plateletcrit; WBC: white blood cell count; LYM: lymphocyte count; GRA: granulocyte count. Statistical analysis using one-way ANOVA, followed by Dunnett’s posttest. versus EAC and versus FU.