Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study

Table 1

Effects of the standard drugs and their combined treatments on locomotor activity.

Treatment (dose, mg/kg, p.o.)	Activity counts (s)
Normal control	165.36 ± 9.05
Amitriptyline 10 mg/kg	67.03 ± 5.38
Genistein 10 mg/kg	226.4 ± 12.35
Genistein 5 mg/kg + amitriptyline 5 mg/kg	153.7 ± 13.27
Genistein 10 mg/kg + amitriptyline 5 mg/kg	189.3 ± 10.14
Genistein 10 mg/kg + amitriptyline 10 mg/kg	102.35 ± 14.12

Values are expressed in mean ± SEM, where .
, compared with normal control group.
, compared with normal control group.
, compared with normal control group.