Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?
Table 1
Effect of different treatments on liver and renal functions of bile duct ligated rats.
Treatment
Control
Sham
BDL
Aminoguanidine
L-NAME
ALT
24.3 ± 1.8
56.1 ± 2.1
1012# ± 6.4
290.2 ± 3.5
1517 ± 8.3
AST
126.3 ± 5.9
310.4 ± 5.7
1379# ± 11.0
1102 ± 5.3
1801 ± 6.4
LDH
929.7 ± 6.9
1637 ± 14.7
2607# ± 10.1
2050 ± 18.8
2428 ± 16.1
T. bilirubin
0.02 ± 0.002
0.08 ± 0.003
4.06# ± 0.1
3.51 ± 0.04
6.07 ± 0.07
Urea
11.8 ± 0.4
31.5 ± 0.8
327.7# ± 3.8
172.4 ± 2.7
516.4 ± 5.8
Creatinine
0.24 ± 0.02
0.72 ± 0.05
2.72# ± 0.06
1.95 ± 0.06
2.78 ± 0.02
Data are presented as mean ± S.E., . Significantly different from control at , #significantly different from sham at , and significantly different from BDL at , using one-way ANOVA and Tukey’s post hoc test.
