Research Article
Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties
Table 3
Effect of naproxen and its metal complexes on the number of entries and time spent in elevated plus maze in acute study.
| Group | Dose (mg/kg) | Observed parameters | Open arm entries | Closed arm entries | Total entries | Time spent in open arms | Time spent in closed arms |
| Control | — | 2.3 ± 0.21 | 2.83 ± 0.40 | 5.17 ± 0.47 | 6.83 ± 0.47 | 293.17 ± 0.47 | Diazepam | 2 | 5.17 ± 0.54 | 4.5 ± 0.56 | 9.67 ± 1.02 | 17.83 ± 0.94 | 282.17 ± 0.94 | Naproxen | 25 | 3.17 ± 0.30 | 4.0 ± 0.36 | 7.17 ± 0.54 | 11.67 ± 0.80 | 288.33 ± 0.80 | N-Cu | 25 | 2.83 ± 0.47 | 3.33 ± 0.42 | 7.17 ± 0.47 | 7.67 ± 0.80 | 292.33 ± 0.80 | N-Co | 25 | 3.33 ± 0.33 | 3.67 ± 0.33 | 7.0 ± 0.57 | 13.5 ± 0.99 | 286.5 ± 1.07 | N-Fe | 25 | 1.83 ± 0.30 | 4.0 ± 0.36 | 5.83 ± 0.16 | 4.0 ± 0.63 | 296.0 ± 0.63 | N-Ag | 25 | 1.5 ± 0.34 | 3.83 ± 0.33 | 5.17 ± 0.40 | 3.67 ± 0.71 | 296.33 ± 0.71 | N-Zn | 25 | 3.17 ± 0.49 | 3.5 ± 0.42 | 6.67 ± 0.60 | 12.67 ± 1.33 | 287.33 ± 1.33 |
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Each value represents the mean ± SEM, . and were considered significant compared with control.
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