Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Table 3

Effect of naproxen and its metal complexes on the number of entries and time spent in elevated plus maze in acute study.

Group	Dose (mg/kg)	Observed parameters
		Open arm entries	Closed arm entries	Total entries	Time spent in open arms	Time spent in closed arms
Control	—	2.3 ± 0.21	2.83 ± 0.40	5.17 ± 0.47	6.83 ± 0.47	293.17 ± 0.47
Diazepam	2	5.17 ± 0.54	4.5 ± 0.56	9.67 ± 1.02	17.83 ± 0.94	282.17 ± 0.94
Naproxen	25	3.17 ± 0.30	4.0 ± 0.36	7.17 ± 0.54	11.67 ± 0.80	288.33 ± 0.80
N-Cu	25	2.83 ± 0.47	3.33 ± 0.42	7.17 ± 0.47	7.67 ± 0.80	292.33 ± 0.80
N-Co	25	3.33 ± 0.33	3.67 ± 0.33	7.0 ± 0.57	13.5 ± 0.99	286.5 ± 1.07
N-Fe	25	1.83 ± 0.30	4.0 ± 0.36	5.83 ± 0.16	4.0 ± 0.63	296.0 ± 0.63
N-Ag	25	1.5 ± 0.34	3.83 ± 0.33	5.17 ± 0.40	3.67 ± 0.71	296.33 ± 0.71
N-Zn	25	3.17 ± 0.49	3.5 ± 0.42	6.67 ± 0.60	12.67 ± 1.33	287.33 ± 1.33

Each value represents the mean ± SEM, . and were considered significant compared with control.