Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves

Figure 4

Effect of PEFRE on histopathological changes in the brain of normal and 6-OHDA treated animals (H&E staining; original magnification, 40x). (a) Normal control showing normal brain architecture. (b) Rats treated with 6-OHDA showing degeneration of neurons. (c) Rats treated with 6-OHDA and Levodopa (6 mg/kg) showing minimal changes in neuronal cell integrity and architecture. (d) Rats treated with 6-OHDA and PEFRE (100 mg/kg) showing mild decrease in neurons and cellular hypertrophy. (e) PEFRE (200 mg/kg) and (f) PEFRE (400 mg/kg) treated rats showing minimal changes in neuronal cell populations.

(a)

(b)

(c)

(d)

(e)

(f)