Downregulation of Thromboxane A₂ Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery

Table 2

Maximal contractile response and pEC₅₀ values to U46619 in rat renal arteries following organ culture for 24 h in presence of vehicle (DMSO) or different concentration of NF-κB inhibitors.

Groups		U46619
		(%)	pEC50
Vehicle	6	113.7 ± 2.30	6.52 ± 0.02
MG 0.2 μM	6
MG 1 μM	6
MG 5 μM	6
vehicle	6	129.3 ± 4.19	6.41 ± 0.04
BMS 1 μM	6	130.7 ± 5.52	6.75 ± 0.07
BMS 5 μM	6	125.8 ± 7.49
BMS 25 μM	6	143.7 ± 11.68

Overview of and pEC₅₀ values of U46619-induced contractile response on rat renal arteries. The segments were organ cultured for 24 h in presence of vehicle (control) or different concentrations of MG-132 (MG 0.2, 1, or 5 μM) or BMS345541 (BMS 1, 5, or 25 μM). Data are shown as mean ± SEM. denotes the number of vessel segments. One-way ANOVA with Dunnett’s multiple comparison test was used. ,  ,   versus vehicle.