Tenofovir Disoproxil Fumarate Is Associated with a Set-Point Variation in the Calcium-Parathyroid Hormone-Vitamin D Axis: Results from a German Cohort

Figure 3

Fractional polynomial plots of predicted PTH concentration for serum 25(OH)D concentrations in patients with and without TDF-containing ART. Black dotted lines demonstrate that the degree of PTH suppression as found in non-TDF-treated patients at a threshold of 20 ng/mL (vitamin D deficiency) is only found at much higher 25(OH)D concentrations in PLWH on TDF-ART.