Research Article
Tenofovir Disoproxil Fumarate Is Associated with a Set-Point Variation in the Calcium-Parathyroid Hormone-Vitamin D Axis: Results from a German Cohort
Table 1
Patient characteristics of groups with and without TDF-containing ART.
| | | Unit | TDF () | Non-TDF () | value |
| | Age | Years (IQR) | 47 (38–53) | 50 (42–58) | <0.001 | | Male | N (%) | 429 (76.1) | 357 (81.5) | 0.038 | | African ethnicity | N (%) | 91 (16.1) | 33 (7.5) | <0.001 | | Missing data | N (%) | 1 (0.2) | 0 (0.0) | | | Creatinine (S) | mg/dL (IQR) | 0.95 (0.82–1.07) | 1.00 (0.86–1.11) | <0.001 | | 25(OH)D (S) | ng/mL (IQR) | 23.0 (14.9–31.1) | 23.6 (16.5–30.4) | 0.366 | | 25(OH)D < 20 ng/mL | N (%) | 230 (40.8) | 165 (37.7) | 0.998 | | Total calcium (S) | mmol/L (IQR) | 2.22 (2.16–2.28) | 2.25 (2.18–2.31) | <0.001 | | Albumin-corrected calcium | mmol/L (IQR) | 2.20 (2.14–2.26) | 2.22 (2.17–2.28) | <0.001 | | Albumin-corrected calcium < 2.12 mmol/L | N (%) | 96 (17.0) | 43 (9.8) | 0.001 | | Phosphate | mg/dL (IQR) | 3.4 (3.0–3.8) | 3.4 (3.0–3.8) | 0.392 | | PTH (S) | pg/mL (IQR) | 44.3 (29.9–61.9) | 33.7 (22.5–49.3) | <0.001 | | Elevated PTH | N (%) | 121 (21.5) | 46 (10.5) | <0.001 | | C-terminal telopeptides of collagen type 1 (S) | µg/L (IQR) | 0.38 (0.25–0.52) | 0.28 (0.20–0.42) | <0.001 | | Elevated C-terminal telopeptides of collagen type 1 | N (%) | 49 (8.7) | 25 (5.7) | 0.074 | | Alkaline phosphatase (S) | U/L (IQR) | 83 (68–101) | 74 (61–93) | <0.001 |
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