Research Article

Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films

Table 1

Characteristics of the edible film and microsphere content of taste strip formulations.

FormulationEdible film componentsMicrosphere content

1Peppermint-sucralose film baseNo microspheres
2Peppermint-sucralose film baseEmpty (blank) microspheres
3Peppermint-sucralose film baseQuinine + empty microspheres
4Peppermint-sucralose film baseQuinine + sucralose microspheres

For formulations 2–4, each one-inch square edible taste film contained 3.75 mg of lipid microspheres. Empty microspheres were included in formulations 2 and 3 so that microsphere density was uniformly maintained in formulations 2 through 4.