Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Table 3

Antioxidant activity of astragalin in vitro and in vivo.

Assay	Organism tested	Dose/concentration	Molecular targets	References
Free radical-scavenging activity		1, 3, 10, 30, 100, or 300 µg/mL		[107]
Inhibitory activity against autophagy-associated airway epithelial fibrosis	Mice	1–20 M	E-cadherin^┴, vimentin^┴, Beclin-1^↓, LC3A/B^↓, EMT^↓, and TGF-β1^┴	[132]
Apoptotic and eosinophilia amelioration	BEAS-2B cells	1–20 M	TLR-4^↓, Eotaxin-1^↓, PLCγ1^↓, PKCβ2^↓, p-p22^↓, p-47^↓, JNK^↓, p38 MAPK^↓, Akt^↑, and ERK^↑	[129]
Suppression of 6-hydroxydopamine-induced neurotoxicity in Caenorhabditis elegans	C. elegans	2.0 mg/mL	egl-1^↓, SOD^↑, GPX^↑, AChe^↑, and p38 MAPK^↓	[130]
Neuroprotective effect against ischemic brain injury	Wister rats	5 mg/kg and 15 mg/kg	NCam^↑	[131]

^↑Upregulation; ^↓downregulation; ^┴inhibition.