Current Trends on Solid Dispersions: Past, Present, and Future

Table 10

In vivo studies with solid dispersion.

Drug name	Carrier used	Method used	Activity	Reference
IIIM-290	PVP K30	Solvent evaporation	Anticancer	[88]
9-nitrocamptotheci	Soluplus®	Solvent evaporation	Anticancer	[97]
(−)-oleocanthal	(+)-xylitol	Hot melt fusion	Anticancer	[106]
Zinc(II)-curcumin complex	PVP K30	Solvent evaporation	Anticancer	[84]
Selaginella doederleinii hieron	PVP K30	Coprecipitation	Anticancer	[107]
Benznidazole	Low substituted HPC	Solvent evaporation	Antichagasic	[90]
Curcumin (CM)	PVP K30	Coprecipitation	Antimicrobial	[98]
Taurine-zinc complex	PVP K30	Spray drying	Antioxidant	[108]
Triacetylated andrographolide (TA)	Kollidon (VA64)	Solvent evaporation	Anti-inflammatory	[109]
Curcumin	PVP K30, poloxamer 188	Solvent evaporation	Anti-inflammatory	[110]
Aceclofenac	Crospovidone	Solvent evaporation	Anti-inflammatory	[111]
Curcumin	Gelucire®50/13-aerosil®	Hot melt fusion	Anti-inflammatory	[112]
Curcumin	HPMC, lecithin and isomalt	Hot melt extrusion	Anti-inflammatory	[113]
Ibuprofen	PEG 8000	Fusion method	Anti-inflammatory	[114]
Flurbiprofen	Urea and mannitol	Fusion method	Anti-inflammatory	[115]
Meloxicam	Paracetamol	Coprecipitation	Anti-inflammatory	[116]
Chelerythrine (CHE)	PVP K30	Solvent evaporation	Anti-inflammatory	[117]
Curcumin	HPMC	Solvent evaporation	Hepatoprotective	[105]
Nobiletin	HPC	Spray drying	Hepatoprotective	[118]
Silymarin	PVP K30	Solvent evaporation	Hepatoprotective	[119]
Repaglinide	Poloxamer 188	Fusion method	Antihyperglycemic	[120]
Glimepiride	Soluplus1 and PEG 4000	Solvent evaporation	Antidiabetic	[121]
Pioglitazone	PVP K17	Spray drying	Antihyperglycemic	[122]
Hecogenin acetate	HPMC	Kneading	Antinociceptive	[63]

PVP, polyvinylpyrrolidone; SD, solid dispersion; HPC, hydroxypropyl cellulose; CM, curcumin; CM/PVP SD, curcumin/polyvinylpyrrolidone solid dispersion; SOD, superoxide dismutase; PEG, polyethylene glycol; TNF-α, tumour necrosis factor alpha; IL, interleukin; NO, nitric oxide; HPMC, hydroxypropyl methylcellulose; and AST, aspartate aminotransferase.