Research Article
Comparative Direct Compression Property of a Novel Pregelatinized Starch in Paracetamol Tablets
Table 3
The properties of tablets of PGTBIS containing magnesium stearate (MgS) (0–2%).
| ∗MgS (%) | Starch type | Weight (mg) | ∗TBF (N) | ∗TS (MPa) | ∗LSR | Friability (%) | DT (min) |
| 0.00 | PGTBIS | 301 ± 7 | 136.3 ± 5.1 | 2.34 ± 0.07 | 0.00 | 0.22 ± 0.01 | 3.2 ± 0.2 | Starch 1500® | 303 ± 14 | 91.1 ± 4.0 | 1.44 ± 0.08 | 0.00 | 0.47 ± 0.01 | 6.2 ± 0.2 |
| 0.25 | PGTBIS | 302 ± 5 | 92.4 ± 4.2 | 1.54 ± 0.08 | 0.34 | 0.39 ± 0.01 | 4.0 ± 0.0 | Starch 1500® | 303 ± 8 | 63.0 ± 2.6 | 1.02 ± 0.03 | 0.29 | 0.71 ± 0.01 | 6.6 ± 0.2 |
| 0.50 | PGTBIS | 303 ± 6 | 75.9 ± 5.2 | 1.23 ± 0.09 | 0.47 | 0.56 ± 0.01 | 6.2 ± 0.3 | Starch 1500® | 303 ± 8 | 56.8 ± 2.6 | 0.90 ± 0.04 | 0.38 | 1.05 ± 0.01 | 8.0 ± 0.2 |
| 0.75 | PGTBIS | 302 ± 5 | 54.8 ± 3.9 | 0.89 ± 0.07 | 0.62 | 1.09 ± 0.04 | 6.9 ± 0.3 | Starch 1500® | 302 ± 4 | 55.4 ± 2.5 | 0.87 ± 0.04 | 0.40 | 1.20 ± 0.01 | 8.9 ± 0.2 |
| 1.00 | PGTBIS | 302 ± 4 | 49.2 ± 3.7 | 0.80 ± 0.07 | 0.66 | 1.12 ± 0.01 | 7.8 ± 0.4 | Starch 1500® | 301 ± 6 | 49.8 ± 2.2 | 0.78 ± 0.03 | 0.46 | 1.35 ± 0.01 | 10.0 ± 0.2 |
| 1.50 | PGTBIS | 302 ± 3 | 33.1 ± 5.9 | 0.54 ± 0.09 | 0.77 | 4.70 ± 0.20 | 9.6 ± 0.5 | Starch 1500® | 302 ± 4 | 32.9 ± 2.0 | 0.51 ± 0.03 | 0.65 | 5.30 ± 0.01 | 11.0 ± 0.2 |
| 2.00 | PGTBIS | 299 ± 3 | 16.6 ± 4.7 | 0.27 ± 0.08 | 0.89 | 8.75 ± 1.20 | 11.9 ± 0.5 | Starch 1500® | 300 ± 4 | 14.0 ± 1.0 | 0.22 ± 0.02 | 0.85 | Friable | 13.8 ± 0.2 |
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MgS, TBF, TS, and LSR stand for magnesium stearate, tablet-breaking force, tensile strength, and lubricant sensitivity ratio, respectively. |