Research Article
Comparative Direct Compression Property of a Novel Pregelatinized Starch in Paracetamol Tablets
Table 4
Properties of tablets compressed at 17 kN of various paracetamol concentrations.
| Drug (%) | Starch type | Weight (mg) | TBF (N) | TS (MPa) | Friability (%) | DT (min) |
| 20 | PGTBIS | 302 ± 3 | 77.4 ± 6.1 | 1.34 ± 0.09 | 0.61 ± 0.01 | 2.0 ± 0.1 | Starch 1500® | 300 ± 3 | 64.7 ± 3.1 | 1.10 ± 0.07 | 0.79 ± 0.02 | 5.7 ± 0.1 |
| 30 | PGTBIS | 300 ± 3 | 69.9 ± 4.2 | 1.19 ± 0.07 | 0.80 ± 0.02 | 1.0 ± 0.1 | Starch 1500® | 302 ± 3 | 51.5 ± 1.8 | 0.87 ± 0.04 | 1.11 ± 0.05 | 4.3 ± 0.2 |
| 40 | PGTBIS | 303 ± 4 | 56.6 ± 4.2 | 0.95 ± 0.07 | 1.60 ± 0.06 | 0.8 ± 0.0 | Starch 1500® | 301 ± 5 | 43.4 ± 1.7 | 0.73 ± 0.04 | 3.00 ± 0.09 | 3.5 ± 0.1 |
| 50 | PGTBIS | 301 ± 6 | 16.1 ± 3.2 | 0.26 ± 0.04 | Friable | 0.5 ± 0.0 | Starch 1500® | 301 ± 6 | 15.1 ± 1.2 | 0.25 ± 0.03 | Friable | 3.0 ± 0.0 |
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TS and DT stand for tensile strength and disintegration time, respectively. |