Comparative Direct Compression Property of a Novel Pregelatinized Starch in Paracetamol Tablets

Table 4

Properties of tablets compressed at 17 kN of various paracetamol concentrations.

Drug (%)	Starch type	Weight (mg)	TBF (N)	TS (MPa)	Friability (%)	DT (min)
20	PGTBIS	302 ± 3	77.4 ± 6.1	1.34 ± 0.09	0.61 ± 0.01	2.0 ± 0.1
	Starch 1500®	300 ± 3	64.7 ± 3.1	1.10 ± 0.07	0.79 ± 0.02	5.7 ± 0.1
30	PGTBIS	300 ± 3	69.9 ± 4.2	1.19 ± 0.07	0.80 ± 0.02	1.0 ± 0.1
	Starch 1500®	302 ± 3	51.5 ± 1.8	0.87 ± 0.04	1.11 ± 0.05	4.3 ± 0.2
40	PGTBIS	303 ± 4	56.6 ± 4.2	0.95 ± 0.07	1.60 ± 0.06	0.8 ± 0.0
	Starch 1500®	301 ± 5	43.4 ± 1.7	0.73 ± 0.04	3.00 ± 0.09	3.5 ± 0.1
50	PGTBIS	301 ± 6	16.1 ± 3.2	0.26 ± 0.04	Friable	0.5 ± 0.0
	Starch 1500®	301 ± 6	15.1 ± 1.2	0.25 ± 0.03	Friable	3.0 ± 0.0

TS and DT stand for tensile strength and disintegration time, respectively.