Exploring the Effect of Compound Glycyrrhizin and Silybinin on the Metabolism of Pexidartinib in Rats Based on CYP3A4 and CYP2C9

<div>(a): The accuracy, and precision of PXD in rat plasma (<i>n</i> = 6); (b): recovery and matrix effect of PXD from rat plasma (<i>n</i> = 6); (c): stability of PXD in rat plasma subjected to various conditions (<i>n</i> = 6); (d): major pharmacokinetic properties of PXD in rats (<i>n</i> = 6, mean ± SD).</div>

Advances in Pharmacological and Pharmaceutical Sciences

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Figure 3: Exploring the Effect of Compound Glycyrrhizin and Silybinin on the Metabolism of Pexidartinib in Rats Based on CYP3A4 and CYP2C9 