Review Article
Busting the Breast Cancer with AstraZeneca’s Gefitinib
Table 4
The pharmacological parameters of Gefitinib [
154,
155,
156].
| | Gefitinib |
| | Target | HER1/EGFR/EGFR1 |
| | Chemical formula | C22H24ClFN4O3 |
| | Absolute bioavailability | 60% |
| | Protein binding | 90% |
| | Cytochrome P450 (CYP) | Major | Cytochrome P450 3A4 (CYP3A4), cytochrome P450 2D6 (CYP2D6) | | Minor | Cytochrome P450 1A1 (CYP1A1) | | Inhibits | CYP2D6, cytochrome P450 2C19 (CYP2C19) |
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