Busting the Breast Cancer with AstraZeneca’s Gefitinib

Table 5

Effects of CYP3A4 inducers and inhibitor.

CYP3A4 inducer	CYP3A4 inhibitor	Changes in Cmax	Changes in AUC	Alternatives and recommendations
Rifampin		65% decrease	83% decrease	Increase the dosage to 500 mg per day [155, 158]
Phenytoin [154]		26% decrease	47% decrease
	Itraconazole	51% increase	78% increase	Not recommended; if unavoidable, the adverse effects must be closely monitored [155, 158]

CYP3A4, cytochrome P450 3A4; C_max, peak plasma concentration; AUC, area under the curve.