Investigations on Polymeric Nanoparticles for Ocular Delivery

Figure 7

(I) CSLM image of rhodamine 6G loaded (a) FX-CH-Rd nanoparticles; (b) Rd solution; the arrows indicate the depth of penetration of rhodamine 6G; (II) cross section of cornea treated with (a) optimized formulation; (b) marketed formulation; (c) phosphate buffer saline (negative control); (d) sodium dodecyl sulfate (positive control); the arrows indicate the presence of intact corneal layers in (a), (b), and (c) and disrupted corneal layers in (d).