Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

Table 4

Models of in-vitro drug release kinetics of PEG-g-poly (MAA) nanogels formulations with varying concentration of polymer, PEG.

Model	Parameters	N1		N2		N3
		pH 1.2	pH 6.8	pH 1.2	pH 6.8	pH 1.2	pH 6.8
Zero order		4.262	35.134	4.407	36.090	4.547	36.242
		0.6392	0.8944	0.5577	0.8602	0.4472	0.8848
First order		0.045	0.699	0.047	0.755	0.049	0.744
		0.6745	0.9714	0.5985	0.9705	0.4943	0.9606
Higuchi		6.473	52.002	6.724	53.646	6.975	53.691
		0.9707	0.9370	0.9526	0.9381	0.9195	0.9353
Korsmeyer Peppas		7.019	46.224	7.523	49.275	8.087	48.119
		0.9891	0.9598	0.9910	0.9510	0.9927	0.9551
		0.380	0.667	0.333	0.621	0.278	0.656