Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

Table 6

Models of in-vitro drug release kinetics of PEG-g-poly (MAA) nanogels formulations with varying concentration of MBA.

Model	Parameters	N7		N8		N9
		pH 1.2	pH 6.8	pH 1.2	pH 6.8	pH 1.2	pH 6.8
Zero order		4.009	32.813	3.943	31.626	3.815	30.462
		0.6420	0.8898	0.6917	0.9162	0.6872	0.9252
First order		0.042	0.619	0.042	0.567	0.040	0.529
		0.6749	0.9839	0.7214	0.9783	0.7163	0.9850
Higuchi		6.088	48.658	5.969	46.659	5.777	44.922
		0.9703	0.9486	0.9809	0.9335	0.9773	0.9393
Korsmeyer Peppas		6.595	43.932	6.341	40.401	6.134	38.761
		0.9881	0.9665	0.9905	0.9654	0.9867	0.9726
		0.382	0.646	0.411	0.704	0.412	0.708