Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

Table 8

Comparison between drug release of all formulation at pH 1.2 and pH 6.8.

Code	Varying pH	Mean ± SEM	p-value	Sig. difference
N1	Drug release at pH 1.2	6.7 ± 1.5	0.001	Yes
	Drug release at pH 6.8	62 ± 11
N2	Drug release at pH 1.2	7.05 ± 1.6	0.001	Yes
	Drug release at pH 6.8	64.3 ± 11
N3	Drug release at pH 1.2	7.42 ± 1.6	0.001	Yes
	Drug release at pH 6.8	64.9 ± 11
N4	Drug release at pH 1.2	7.09 ± 1.4	0.001	Yes
	Drug release at pH 6.8	51.5 ± 9.2
N5	Drug release at pH 1.2	6.74 ± 1.3	0.001	Yes
	Drug release at pH 6.8	51.1 ± 9.4
N6	Drug release at pH 1.2	6.53 ± 1.3	0.001	Yes
	Drug release at pH 6.8	49.5 ± 8.9
N7	Drug release at pH 1.2	6.76 ± 1.3	0.001	Yes
	Drug release at pH 6.8	50.6 ± 8.8
N8	Drug release at pH 1.2	6.6 ± 1.3	0.001	Yes
	Drug release at pH 6.8	48.3 ± 8.7
N9	Drug release at pH 1.2	6.39 ± 1.3	0.001	Yes
	Drug release at pH 6.8	46.5 ± 8.4